The drive from Lexington, Virginia to Nashville, Tennessee is a scenic 450-mile journey through the Appalachian Mountains. You will primarily travel via I-81 S and I-40 W. This route takes you through the heart of Tennessee, passing through Knoxville. The drive typically takes about 7 to 8 hours depending on traffic in the Nashville metro area. It is a popular route for those looking to experience the musical heritage of the South.
Total Distance: 725 km driving distance; 600 km straight-line air distance.
Stop in Knoxville for a lunch break to break up the drive.
Spring and Fall for mild temperatures and beautiful foliage.