The drive from Lexington, Virginia to Indianapolis, Indiana is approximately 500 miles. The most direct route takes you west through West Virginia and Ohio via I-64 W and I-70 W. This journey takes about 8 hours of driving time. You will cross the Appalachian Mountains and enter the flat plains of the Midwest. It is a straightforward drive that is manageable in a single day.
Total Distance: 800 km driving distance; 650 km straight-line air distance.
Expect heavy traffic near Indianapolis during rush hours.
Spring and Fall for comfortable driving weather.