The drive from Lexington, Virginia to Omaha, Nebraska is approximately 1,250 miles. The most direct route takes you west through Kentucky, Indiana, Illinois, and Missouri via I-70 W and I-29 N. This journey takes about 20 hours of driving time. You will cross the Appalachian Mountains and travel through the heart of the Midwest. It is a long drive that requires careful planning.
Total Distance: 2,010 km driving distance; 1,600 km straight-line air distance.
Plan for overnight stops in cities like St. Louis or Kansas City.
Spring and Fall for comfortable driving weather.