The distance between Mt Vernon, Illinois and Indianapolis, Indiana is approximately 300 kilometers. The most direct route is driving east on I-64 and then north on I-65, which takes about 3 hours. This route takes you through the rolling hills of Southern Indiana. Indianapolis is a major hub for sports and culture in the Midwest.
Total Distance: Driving distance 300 km, straight-line air distance 280 km.
Expect traffic near downtown Indianapolis.
May for the Indianapolis 500 or fall for pleasant weather.