How long is the drive?

It takes about 1 hour and 30 minutes.

Yes, Amtrak's Texas Eagle stops in Centralia, near Mt Vernon.

What is the best way to get around St. Louis?

A car is recommended, but MetroLink is good for downtown.

Like any major city, it has safe and less safe areas; use common sense.

No, I-64 is toll-free between Mt Vernon and St. Louis.

Mt Vernon

St. Louis

Train Driving

Mt Vernon to St. Louis

Updated: 28 May 2026

The distance between Mt Vernon, Illinois and St. Louis, Missouri is approximately 125 kilometers. The most direct route is driving west on I-64, which typically takes about 1 hour and 30 minutes. Alternatively, you can take an Amtrak train from nearby stations like Centralia to reach St. Louis. This route is a common commute for those working in the St. Louis metropolitan area. The journey crosses the Mississippi River into Missouri.

Total Distance: Driving distance 125 km, straight-line air distance 115 km.

Fastest Way

Driving via I-64 is the fastest way to reach downtown St. Louis.

Cheapest Way

Driving is the most cost-effective and flexible option for this short distance.

Compare Mt Vernon to St. Louis Routes

	Train Direct	Driving Direct
Duration	2 hours	1 hour 30 mins
Avg Price	$20 - $40	$15 - $25 in fuel
Operator	Amtrak (Texas Eagle)	Personal Vehicle
Route	Centralia Station to St. Louis Gateway Station.	I-64 W.
Tip	Check the schedule as trains run once daily.	Traffic can be heavy near the Poplar Street Bridge in St. Louis.

Travel Tips

Parking
Use parking garages in downtown St. Louis to avoid street parking hassles.
Traffic
Avoid the I-64/I-55 interchange during rush hour.
Public Transit
Use the MetroLink light rail to get around the city easily.
Dining
Try the famous St. Louis-style pizza and toasted ravioli.
Events
Check the schedule for Cardinals baseball games at Busch Stadium.

Safety Tips

Driving Safety
Be alert for merging traffic on the Poplar Street Bridge.
Personal Safety
Stay in well-lit, populated areas when exploring downtown at night.
Vehicle Security
Always lock your car and keep valuables out of sight.
General Safety
Be aware of your surroundings in crowded tourist areas.