Amtrak's City of New Orleans stops in nearby Centralia, but there is no direct train to Atlanta.

What is the best route?

I-64 East to I-24 East to I-75 South is the standard route.

No, this route is generally toll-free.

Is Atlanta worth the drive?

Yes, it is a major cultural and historical hub in the South.

Mt Vernon

Atlanta

Driving

Mt Vernon to Atlanta

Updated: 28 May 2026

The trip from Mt Vernon to Atlanta is a 450-mile journey that takes approximately 7 hours via I-64 East and I-75 South. You will pass through Louisville and Nashville, two major Southern cities. The route crosses the Ohio River and winds through the scenic hills of Tennessee and Georgia. It is a popular route for those traveling between the Midwest and the Deep South.

Total Distance: 725 km driving distance; 650 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking 7 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective way to travel.

Compare Mt Vernon to Atlanta Routes

Driving

Direct

Duration

7 hours

Avg Price

$80-$100 in fuel

Operator

Personal Vehicle

Route

I-64 E to I-24 E to I-75 S.

Nashville traffic can be very heavy; plan accordingly.

Travel Tips

Route Choice
Take I-64 East to I-24 East, then merge onto I-75 South in Chattanooga.
Dining
Nashville is a great place to stop for hot chicken and live music.
Parking
Atlanta has many public parking garages in the downtown area.
Traffic
Avoid the I-75/I-85 connector in Atlanta during rush hour.
Weather
Be prepared for humidity and sudden rain showers in the summer.

Safety Tips

Highway Safety
Stay alert on I-75, as it is a major corridor with heavy traffic.
Vehicle Prep
Check your coolant and tire pressure before this long drive.
Emergency
Keep a roadside emergency kit in your vehicle.
Navigation
Use a real-time traffic app to avoid construction delays on I-75.