The drive from Murrells Inlet to Boston covers approximately 1400 kilometers. You will primarily use I-95 North. The journey takes about 15 hours. You will travel through North Carolina, Virginia, Maryland, Delaware, New Jersey, New York, Connecticut, and into Massachusetts. This is a very long and busy route with significant traffic near major cities.
Total Distance: 1400 km driving distance; 1300 km straight-line air distance.
Expect heavy traffic and tolls in the Northeast.
Spring and fall offer the best weather for visiting Boston.