Is there a bus to Charlotte?

No, there is no direct public bus service from Murrells Inlet.

How long is the drive?

It usually takes 3.5 hours under normal conditions.

There are express lanes on I-77 that require a toll pass.

No, there is no passenger rail service available.

What is the best route?

Taking US-501 to I-77 is the most direct route.

Murrells Inlet

Charlotte

Driving

Murrells Inlet to Charlotte

Updated: 28 May 2026

The drive from Murrells Inlet to Charlotte covers approximately 350 kilometers. You will travel from the South Carolina coast through the interior and across the border into North Carolina. The most common route uses US-501 and I-77. Driving time is typically 3.5 hours depending on traffic. Personal vehicle is the most practical mode of transport.

Total Distance: 350 km driving distance; 310 km straight-line air distance.

Fastest Way

Driving via US-501 and I-77 in 3.5 hours.

Cheapest Way

Driving your own vehicle is the most economical option.

Compare Murrells Inlet to Charlotte Routes

Driving

Direct

Duration

3 hours 30 mins

Avg Price

$45-$55 in fuel

Operator

Personal Vehicle

Route

US-501 N to I-77 N

Be prepared for heavy traffic when entering Charlotte via I-77.

Travel Tips

Traffic
I-77 can be very congested during morning and evening rush hours.
Parking
Uptown Charlotte has many parking garages, but they can be expensive during events.
Public Transit
Use the LYNX Blue Line light rail to get around the city center easily.
Dining
Charlotte has a diverse food scene; check out the South End neighborhood for trendy spots.
Navigation
Use a GPS to navigate the complex highway system in Charlotte.