The drive from Murrells Inlet to Houston covers approximately 1700 kilometers. You will primarily use I-10 West. The journey takes about 18 hours. You will travel through South Carolina, Georgia, Alabama, Mississippi, Louisiana, and into Texas. This is a long drive across the South.
Total Distance: 1700 km driving distance; 1500 km straight-line air distance.
Expect heavy traffic in Houston.
Spring and fall offer the best weather for visiting Houston.