The drive from Murrells Inlet to New Orleans covers approximately 1300 kilometers. You will primarily use I-20 and I-10 West. The journey takes about 14 hours. You will travel through South Carolina, Georgia, Alabama, Mississippi, and into Louisiana. This is a long drive through the Deep South.
Total Distance: 1300 km driving distance; 1100 km straight-line air distance.
Expect heavy traffic in New Orleans.
Spring and fall offer the best weather for visiting New Orleans.