The drive from Murrells Inlet to New York City covers approximately 1100 kilometers. You will primarily use I-95 North. The journey takes about 12 hours. You will travel through North Carolina, Virginia, Maryland, Delaware, New Jersey, and into New York. This is a very long and busy route with significant traffic near major cities.
Total Distance: 1100 km driving distance; 1000 km straight-line air distance.
Expect heavy traffic and tolls in the Northeast.
Spring and fall offer the best weather for visiting New York City.