The drive from Murrells Inlet to San Antonio covers approximately 2000 kilometers. You will primarily use I-10 West. The journey takes about 21 hours. You will travel through South Carolina, Georgia, Alabama, Mississippi, Louisiana, and into Texas. This is a very long drive across the South.
Total Distance: 2000 km driving distance; 1800 km straight-line air distance.
Expect heavy traffic in San Antonio.
Spring and fall offer the best weather for visiting San Antonio.