Murrells Inlet
Murrells Inlet
San Antonio
San Antonio
Driving

Murrells Inlet to San Antonio

Updated: 28 May 2026

The drive from Murrells Inlet to San Antonio covers approximately 2000 kilometers. You will primarily use I-10 West. The journey takes about 21 hours. You will travel through South Carolina, Georgia, Alabama, Mississippi, Louisiana, and into Texas. This is a very long drive across the South.

Total Distance: 2000 km driving distance; 1800 km straight-line air distance.
Fastest Way
Driving via I-10 is the fastest route, taking about 21 hours.
Cheapest Way
Driving is the most cost-effective way to reach San Antonio.
Compare Murrells Inlet to San Antonio Routes
Driving
Direct
Duration
21 hours
Avg Price
$320-$360 in fuel
Operator
Personal Vehicle
Route
I-10 West through New Orleans, Houston, and Austin.

Expect heavy traffic in San Antonio.

Travel Tips
  • Traffic
    Avoid San Antonio rush hour traffic.
  • Parking
    Parking in San Antonio is generally available.
  • Dining
    Try the local Tex-Mex cuisine.
  • Events
    Check the local calendar for festivals and events.
  • Navigation
    Use a GPS to monitor traffic delays on I-10.
Safety Tips
  • Speeding
    Watch for speed limit changes on I-10.
  • Fatigue
    Take breaks every two hours to stay alert.
  • Emergency
    Keep a roadside emergency kit in your car.
  • Weather
    Be prepared for changing weather conditions.
People Also Ask
  • How long is the drive?
    It takes about 21 hours.
  • Is it a scenic drive?
    It is mostly interstate driving.
  • Are there tolls?
    Some sections of the route have tolls.
  • What is the best highway?
    I-10 West is the primary route.
  • Is it a safe drive?
    Yes, it is a very common and safe route.
Quick Info
  • From Murrells Inlet, South Carolina, United States
  • To San Antonio, Texas, United States
  • Modes
Best Time to Travel

Spring and fall offer the best weather for visiting San Antonio.

Things to Do in San Antonio
1
The Alamo
Visit the historic mission.
2
River Walk
Enjoy the famous river walk.
3
San Antonio Missions National Historical Park
Explore the historic missions.
4
Tower of the Americas
See the city from the observation deck.
Tags
Murrells Inlet to San Antonio driving to San Antonio I-10 route SC to TX San Antonio travel Murrells Inlet road trip Texas San Antonio guide