Flight
Driving
Murrells Inlet to St. Louis
Updated: 28 May 2026
Traveling from the South Carolina coast to St. Louis is best done by car or flight. Driving takes about 13 to 14 hours via I-26 and I-64. Flights from Myrtle Beach International Airport are often connecting. The total flight time is approximately 5 to 6 hours. You will arrive at STL, located northwest of the city.
Total Distance: Driving distance 1,200 km, air distance 1,000 km.
Fastest Way
Direct flight from MYR to STL, total time 2 hours 30 mins.
Cheapest Way
Driving your own vehicle.
Compare Murrells Inlet to St. Louis Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 5 hours | 13 hours |
| Avg Price | 250-500 USD | 200-300 USD (fuel) |
| Operator | Southwest Airlines | Personal Vehicle |
| Route | MYR to STL via BNA or MDW. | I-26 W to I-64 W. |
| Tip | Check for direct seasonal flights. | Expect heavy traffic near Louisville. |
Travel Tips
-
DrivingBe prepared for long stretches of highway driving.
-
Public TransitUse the MetroLink light rail for city travel.
-
DiningTry the local St. Louis-style pizza.
-
WeatherPrepare for hot, humid summers.
-
ParkingUse parking garages in the downtown area.
Safety Tips
-
Driving SafetyStay alert for construction zones on I-64.
-
Pedestrian SafetyUse crosswalks in the busy downtown area.
-
Night SafetyStay in well-lit areas when visiting downtown.
-
EmergencyKeep a roadside emergency kit in your car.
People Also Ask
-
Is driving better than flying?Driving is cheaper, but flying is much faster.
-
How long is the drive?Expect about 13 to 14 hours of driving time.
-
Are there tolls?Some routes may have tolls, check your GPS.
-
What is the best airport?St. Louis Lambert International Airport.
-
Is it safe to walk?Yes, downtown is generally safe and walkable.
Quick Info
- From Murrells Inlet, South Carolina, United States
- To St. Louis, Missouri, United States
-
Modes
Best Time to Travel
April to June or September to October for pleasant weather.
Things to Do in St. Louis
1
Gateway Arch
Visit the iconic monument and museum.
2
Forest Park
Explore the massive park with museums and the zoo.
3
City Museum
Visit the unique, interactive museum.
4
Anheuser-Busch Brewery
Take a tour of the historic brewery.
Tags
Murrells Inlet to St. Louis
driving to St. Louis from SC
flights to STL from SC
traveling to Missouri
Myrtle Beach to St. Louis
St. Louis travel guide
SC to MO travel
best way to visit St. Louis
STL airport tips
Midwest travel
