The journey from Myrtle Beach to Columbia is approximately 150 miles. Driving is the most practical and common method, taking about 2 hours and 30 minutes via SC-378 West. This route takes you from the coast into the interior of South Carolina, offering a mix of rural landscapes and urban scenery. There is no direct train or bus service that is more efficient than driving.
Total Distance: 240 km driving distance; 210 km straight-line air distance.
The route is straightforward, but be mindful of speed limits in small towns.
April to June or September to October for mild weather.