Driving
Winston-Salem to Cincinnati
Updated: 28 May 2026
The drive from Winston-Salem to Cincinnati is approximately 400 miles, following I-77 North and I-74 West. The trip takes about 6.5 hours, passing through the scenic mountains of West Virginia. Cincinnati is a historic city on the banks of the Ohio River, known for its vibrant cultural scene and unique culinary traditions. There is no direct passenger rail service, making driving the most practical and popular choice.
Total Distance: 640 km driving distance; 550 km straight-line air distance.
Fastest Way
Driving via I-77 and I-74 is the fastest method, taking about 6.5 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective way to travel.
Compare Winston-Salem to Cincinnati Routes
Driving
Direct
Duration
6 hours 30 mins
Avg Price
$70-$90 in fuel
Operator
Personal Vehicle
Route
I-77 N to I-74 W
The mountain roads in West Virginia can be winding; drive with caution.
Travel Tips
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TrafficCincinnati traffic can be heavy; use navigation apps to avoid gridlock.
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ParkingDowntown Cincinnati has several public parking garages that are reasonably priced.
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DiningTry the local food scene, which is known for its unique culinary traditions.
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NavigationUse a GPS app to navigate around potential construction zones on the interstate.
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EventsCheck the city calendar for festivals and events in the downtown area.
Safety Tips
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Highway SafetyStay alert for heavy traffic and merging vehicles on the interstate.
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WeatherBe prepared for cold weather if traveling during the winter months.
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Vehicle SafetyCheck your fluid levels before departing for the 6.5-hour drive.
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EmergencyKeep a roadside assistance contact number handy for interstate travel.
People Also Ask
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Is there a train to Cincinnati?No, there is no direct passenger rail service from Winston-Salem.
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How long is the drive?The drive is approximately 6.5 hours.
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Is it a safe route?Yes, it is a standard interstate drive.
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What is the best route?I-77 North to I-74 West is the most efficient path.
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Are there tolls?Yes, there are some toll roads in the Midwest.
Quick Info
- From Winston-Salem, North Carolina, United States
- To Cincinnati, Ohio, United States
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Modes
Best Time to Travel
Spring and Fall are ideal for exploring the city's riverfront and historic sites.
Things to Do in Cincinnati
1
Cincinnati Art Museum
Explore one of the oldest art museums in the United States, featuring a wide variety of collections.
2
Cincinnati Zoo and Botanical Garden
Visit one of the oldest and most popular zoos in the country.
3
Findlay Market
Enjoy a wide variety of local food and goods in this historic indoor market.
4
National Underground Railroad Freedom Center
Learn about the history of the Underground Railroad through powerful exhibits.
Tags
Winston-Salem to Cincinnati drive
I-77 to I-74 route
driving to Cincinnati OH
NC to OH travel
Cincinnati OH travel guide
Winston-Salem to Cincinnati distance
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