The drive from Winston-Salem to Las Vegas is a massive 3,600-kilometer cross-country trek. You will primarily follow I-40 West before heading north into Nevada. Expect a travel time of at least 34 hours of pure driving. This route takes you through the heart of the American Southwest.
Total Distance: 3,600 km driving, 3,200 km air distance.
Plan for at least two overnight stops.
Spring or Fall to avoid extreme desert heat.