Driving
Winston-Salem to Louisville
Updated: 28 May 2026
The drive from Winston-Salem to Louisville covers approximately 700 kilometers. You will travel north through Virginia and West Virginia before entering Kentucky. The primary highways are I-77 and I-64. Expect a travel time of about 7 hours. This route takes you through the beautiful Appalachian Mountains.
Total Distance: 700 km driving, 600 km air distance.
Fastest Way
Driving is the fastest practical way to reach Louisville.
Cheapest Way
Driving is the most cost-effective option.
Compare Winston-Salem to Louisville Routes
Driving
Direct
Duration
7 hours
Avg Price
$80-$120 in fuel
Operator
Personal Vehicle
Route
I-77 N to I-64 W
Plan for a stop in Charleston, West Virginia.
Travel Tips
-
TrafficAvoid Louisville rush hour traffic.
-
Rest StopsUse the rest areas along I-64.
-
NavigationUse GPS to navigate the city streets.
-
HydrationKeep water in the car for the long drive.
-
SnacksPack a cooler with food to save money.
Safety Tips
-
FatigueTake breaks every 3 hours.
-
Speed LimitsWatch for speed traps in rural areas.
-
WeatherCheck for storms in the mountains.
-
Vehicle CheckCheck your tire pressure before leaving.
People Also Ask
-
Is Louisville safe?Stick to tourist areas and be aware of your surroundings.
-
How long is the drive?It takes about 7 hours.
-
Are there flights?Yes, direct flights are available from major airports.
-
What is the best route?I-77 N to I-64 W is the standard path.
-
Is it a scenic route?The drive through the mountains is quite beautiful.
Quick Info
- From Winston-Salem, North Carolina, United States
- To Louisville, Kentucky, United States
-
Modes
Best Time to Travel
Spring or Fall for mild weather.
Things to Do in Louisville
1
Churchill Downs
The home of the Kentucky Derby. It is a must-see for horse racing fans.
2
Louisville Slugger Museum
A museum dedicated to the history of the baseball bat.
3
Muhammad Ali Center
A museum dedicated to the life and legacy of the boxing legend.
4
Big Four Bridge
A pedestrian bridge connecting Louisville to Indiana.
Tags
Winston-Salem to Louisville
driving to Kentucky
I-77 to I-64 route
Louisville travel guide
NC to KY road trip
long distance driving
best route to Louisville
traveling north
