The drive from Winston-Salem to New Orleans covers approximately 1,200 kilometers. You will travel south through South Carolina, Georgia, and Alabama before entering Louisiana. The primary highways are I-85 and I-65. Expect a travel time of about 12 hours. This route takes you through the heart of the Deep South.
Total Distance: 1,200 km driving, 1,050 km air distance.
Plan for a stop in Birmingham, Alabama.
Spring or Fall for mild weather.