Driving
Winston-Salem to San Antonio
Updated: 28 May 2026
The drive from Winston-Salem to San Antonio covers approximately 1,950 kilometers. You will travel west through Georgia, Alabama, Mississippi, and Louisiana before entering Texas. The primary highways are I-20 and I-35. Expect a travel time of about 20 hours. This route takes you through the heart of the South.
Total Distance: 1,950 km driving, 1,750 km air distance.
Fastest Way
Driving is the fastest practical way to reach San Antonio.
Cheapest Way
Driving is the most cost-effective option.
Compare Winston-Salem to San Antonio Routes
Driving
Direct
Duration
20 hours
Avg Price
$220-$320 in fuel
Operator
Personal Vehicle
Route
I-20 W to I-35 S
Plan for an overnight stop in Louisiana.
Travel Tips
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TrafficAvoid San Antonio rush hour traffic.
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Rest StopsUse the rest areas along I-20.
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NavigationUse GPS to navigate the city streets.
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HydrationKeep water in the car for the long drive.
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SnacksPack a cooler with food to save money.
Safety Tips
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FatiguePlan for an overnight stop.
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Speed LimitsWatch for speed traps in rural areas.
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WeatherCheck for storms in the South.
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Vehicle CheckCheck your tire pressure before leaving.
People Also Ask
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Is San Antonio safe?Stick to tourist areas and be aware of your surroundings.
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How long is the drive?It takes about 20 hours.
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Are there flights?Yes, direct flights are available from major airports.
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What is the best route?I-20 W to I-35 S is the standard path.
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Is it a scenic route?The drive through the South is quite beautiful.
Quick Info
- From Winston-Salem, North Carolina, United States
- To San Antonio, Texas, United States
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Modes
Best Time to Travel
Spring or Fall for mild weather.
Things to Do in San Antonio
1
The Alamo
A historic mission and fortress. It is a symbol of Texas independence.
2
River Walk
A beautiful network of walkways along the San Antonio River. It is full of shops and restaurants.
3
San Antonio Missions
A UNESCO World Heritage site featuring historic missions.
4
Tower of the Americas
A tall tower offering great views of the city.
Tags
Winston-Salem to San Antonio
driving to Texas
I-20 W route
San Antonio travel guide
NC to TX road trip
long distance driving
best route to San Antonio
traveling west
