Driving
Cape Girardeau to Des Moines
Updated: 28 May 2026
The journey from Cape Girardeau to Des Moines is approximately 700 kilometers. Driving takes about 7 hours via I-55 N and I-35 N. Des Moines is the capital of Iowa and features a growing arts and dining scene. A car is essential for exploring the city and surrounding areas.
Total Distance: Driving distance 710 km; straight-line air distance 580 km.
Fastest Way
Driving is the fastest method.
Cheapest Way
Driving is the only practical method for this route.
Compare Cape Girardeau to Des Moines Routes
Driving
Direct
Duration
7 hours
Avg Price
$80 in fuel
Operator
Personal Vehicle
Route
I-55 N to I-35 N
The drive is straightforward through the Midwest.
Travel Tips
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Car RentalA car is essential for getting around.
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DiningThe East Village has a great food scene.
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WeatherBe prepared for hot summers and cold winters.
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ParkingParking is generally easy and affordable.
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EventsCheck for local festivals in the downtown area.
Safety Tips
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General SafetyDes Moines is generally safe; use standard precautions.
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DrivingBe cautious of winter road conditions.
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EmergencyDial 911 for assistance.
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Night SafetyStay in well-lit areas at night.
People Also Ask
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Is Des Moines safe?Yes, it is considered a safe city for visitors.
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How long is the drive?Approximately 7 hours.
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Are there direct flights?No, you must connect through a hub.
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What is the best time to visit?Summer is best for outdoor activities.
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Is public transit good?It is limited; a car is recommended.
Quick Info
- From Cape Girardeau, Missouri, United States
- To Des Moines, Iowa, United States
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Modes
Best Time to Travel
Late spring to early autumn for pleasant weather.
Things to Do in Des Moines
1
State Capitol
Visit the beautiful gold-domed capitol building.
2
Greater Des Moines Botanical Garden
Explore the geodesic dome and outdoor gardens.
3
Pappajohn Sculpture Park
Walk through this outdoor park featuring world-class sculptures.
4
East Village
Browse local shops and restaurants in this historic neighborhood.
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