Flight
Driving
Des Peres to Jacksonville
Updated: 31 May 2026
The journey from Des Peres to Jacksonville is approximately 1,400 km. You can drive via I-64 E and I-75 S, which takes about 14 hours. Alternatively, you can fly from St. Louis Lambert International Airport to Jacksonville International Airport.
Total Distance: 1,400 km driving distance; 1,200 km straight-line air distance.
Fastest Way
Flying takes 2.5 hours.
Cheapest Way
Driving is the most economical for groups.
Compare Des Peres to Jacksonville Routes
|
Direct
|
Direct
|
|
|---|---|---|
| Duration | 2.5 hours | 14 hours |
| Avg Price | $200 - $400 | $180 - $300 |
| Operator | American Airlines | Personal Vehicle |
| Route | STL to JAX. | I-64 E to I-75 S. |
| Tip | Fastest way to travel. | Long drive, plan for stops. |
Travel Tips
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TrafficAvoid Jacksonville rush hour.
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ParkingUse secure parking garages.
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EventsCheck for local events.
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DiningTry local Florida cuisine.
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NavigationUse GPS for city navigation.
Safety Tips
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DrivingStay alert on the highway.
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WeatherCheck for weather alerts.
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VehicleCheck your car before the trip.
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EmergencyKeep a roadside kit.
People Also Ask
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How long is the drive?It takes about 14 hours.
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Is there a train?No, there is no direct rail service.
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Are there tolls?Yes, expect tolls in Florida.
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What is the best way?Flying is the most convenient.
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Is it safe?Yes, it is a standard drive.
Quick Info
- From Des Peres, Missouri, United States
- To Jacksonville, Florida, United States
-
Modes
Best Time to Travel
Spring and Fall for mild weather.
Things to Do in Jacksonville
1
Jacksonville Beach
Enjoy the beach.
2
Cummer Museum
Explore the art museum.
3
Riverside Arts Market
Visit the market.
4
Catty Shack Ranch
See the big cats.
Tags
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