The drive from Lexington, Virginia to Jacksonville, Florida is approximately 650 miles. The most direct route takes you south through North Carolina, South Carolina, and Georgia via I-81 S and I-95 S. This journey takes about 10 to 11 hours of driving time. You will cross the Appalachian Mountains and travel through the heart of the Southeast. It is a long but straightforward drive.
Total Distance: 1,045 km driving distance; 850 km straight-line air distance.
Plan for a stop in Savannah or Charleston.
Winter and Spring for comfortable driving weather.