Driving
Lexington to Key West
Updated: 28 May 2026
The drive from Lexington, Virginia to Key West, Florida is approximately 1,150 miles. The most direct route takes you south through North Carolina, South Carolina, Georgia, and Florida via I-81 S, I-95 S, and US-1 S. This journey takes about 18 to 19 hours of driving time. You will cross the Appalachian Mountains and travel through the heart of the Southeast. It is a long but straightforward drive.
Total Distance: 1,850 km driving distance; 1,500 km straight-line air distance.
Fastest Way
Driving is the fastest method, taking about 19 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective way to reach Key West.
Compare Lexington to Key West Routes
Driving
Direct
Duration
19 hours
Avg Price
$200 - $300 in fuel
Operator
Personal Vehicle
Route
I-81 S to I-95 S to US-1 S.
Plan for a stop in Miami or the Florida Keys.
Travel Tips
-
TrafficKey West traffic can be heavy during peak tourist season.
-
ParkingDowntown parking is limited; use public transport or bikes.
-
WeatherBe prepared for hot and humid weather in the summer.
-
FoodTry the local key lime pie.
-
NavigationUse GPS to navigate the city's grid system.
Safety Tips
-
Road SafetyBe cautious of speed traps on US-1.
-
Vehicle PrepCheck your lights and signals before the trip.
-
Personal SafetyStay in well-lit areas when walking at night.
-
Emergency KitKeep a basic emergency kit in your car.
People Also Ask
-
How long is the drive?The drive takes about 19 hours.
-
Is there a train?No, there is no direct passenger rail service.
-
What is the best route?Taking I-81 S to I-95 S to US-1 S is the most direct path.
-
Is Key West safe?Yes, it is generally safe for visitors.
-
What is the best time to visit?Winter and spring are ideal.
Quick Info
- From Lexington, Virginia, United States
- To Key West, Florida, United States
-
Modes
Best Time to Travel
Winter and Spring for comfortable driving weather.
Things to Do in Key West
1
Duval Street
Enjoy the nightlife and restaurants.
2
Ernest Hemingway Home
Visit the historic home.
3
Southernmost Point
Take a photo at the iconic marker.
4
Mallory Square
Watch the sunset celebration.
Tags
Lexington VA to Key West FL
driving to Key West from Virginia
best route to Key West
road trip Lexington to Key West
traveling to Florida
I-95 to US-1 route
Key West travel guide
US road trip
distance Lexington to Key West
travel tips Florida
