The drive from Lexington, Virginia to Tampa, Florida is approximately 850 miles. The most direct route takes you south through North Carolina, South Carolina, and Georgia via I-81 S and I-75 S. This journey takes about 13 to 14 hours of driving time. You will cross the Appalachian Mountains and travel through the heart of the Southeast. It is a long but straightforward drive.
Total Distance: 1,370 km driving distance; 1,100 km straight-line air distance.
Plan for a stop in Atlanta or Savannah.
Winter and Spring for comfortable driving weather.