Is there a train to Durham?

Yes, Amtrak serves Durham via the Carolinian and Piedmont lines.

How long is the drive?

The drive typically takes 4 hours under normal traffic conditions.

There are no major toll roads on the direct route from Myrtle Beach to Durham.

What is the best route?

Taking US-501 to I-95 and then I-40 is the most efficient path.

Yes, the route consists of well-maintained major highways.

Myrtle Beach

Durham

Bus Driving

Myrtle Beach to Durham

Updated: 28 May 2026

The journey from Myrtle Beach to Durham covers approximately 250 miles through the heart of the Carolinas. Most travelers prefer driving via I-95 North to I-40 West, which takes about 4 hours depending on traffic near Fayetteville. Alternatively, bus services provide a budget-friendly option with transfers in major hubs. You will pass through diverse landscapes ranging from coastal plains to the rolling hills of the Piedmont region. This route is highly accessible and well-maintained throughout the year.

Total Distance: 402 km driving distance; 320 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking roughly 4 hours via major interstates.

Cheapest Way

Bus travel is the cheapest, often costing under $70 if booked early.

Compare Myrtle Beach to Durham Routes

	Bus Connecting	Driving Direct
Duration	6 hours 30 mins	4 hours
Avg Price	$60-$110	$40-$60 in fuel
Operator	Greyhound	Personal Vehicle
Route	Myrtle Beach to Raleigh, then local transit to Durham.	US-501 N to I-95 N, then I-40 W.
Tip	Book tickets at least two weeks in advance for the lowest fares.	Avoid rush hour traffic in Fayetteville to save 30 minutes of travel time.

Travel Tips

Traffic Awareness
Check local traffic apps before leaving Myrtle Beach to avoid congestion on US-501.
Rest Stops
Stop in Lumberton for a variety of dining and fuel options along I-95.
Parking
Use the parking garages in downtown Durham for easy access to major attractions.
Weather
Be prepared for sudden rain showers in the Piedmont region during summer afternoons.
Connectivity
Cell service is reliable along the entire route, making GPS navigation easy.

Safety Tips

Speed Limits
Strictly observe speed limits in small towns along US-501 to avoid fines.
Night Driving
Exercise caution on rural stretches of the highway due to potential wildlife crossings.
Vehicle Check
Ensure your tire pressure is correct before starting your long-distance drive.
Emergency Kit
Keep a basic emergency kit in your trunk, including water and a flashlight.