The journey from Rhinelander to Des Moines covers 650 kilometers and takes approximately 7 hours and 30 minutes. You will travel south on US-51 to I-39, then merge onto I-35 South through Madison and into Iowa. This route takes you through the heart of the Midwest, passing through major cities like Madison and Albert Lea. It is a straightforward interstate drive.
Total Distance: 650 km driving, 560 km air distance.
Expect heavy traffic near Madison and Des Moines during rush hours.
Late spring or early autumn for pleasant driving weather.