Winston-Salem
Winston-Salem
Durham
Durham
Driving

Winston-Salem to Durham

Updated: 28 May 2026

The distance from Winston-Salem to Durham is approximately 70 miles. The most practical way to travel is by driving east on I-40. The drive takes about 1 hour. This route is a major corridor for travel in the Piedmont region of North Carolina.

Total Distance: 115 km driving distance; 100 km straight-line air distance.
Fastest Way
Driving is the fastest way to reach Durham.
Cheapest Way
Driving is the most practical and cost-effective way to travel this distance.
Compare Winston-Salem to Durham Routes
Driving
Direct
Duration
1 hour
Avg Price
$10-$20 in fuel
Operator
Personal Vehicle
Route
Take I-40 East directly into Durham.

I-40 is very busy; check traffic before you leave.

Travel Tips
  • Driving
    I-40 is very busy; avoid driving during rush hour.
  • Parking
    Parking in Durham can be expensive; use public transit.
  • Weather
    North Carolina weather is generally mild; pack accordingly.
  • Traffic
    Check traffic before you leave to avoid delays.
  • Tolls
    There are minimal tolls on this route.
Safety Tips
  • Personal Safety
    Stay in well-lit, populated areas in Durham.
  • Emergency
    Keep your phone charged and have a map of the city saved offline.
  • Highway Safety
    I-40 requires constant attention; stay alert.
  • Vehicle Security
    Never leave valuables in your car.
People Also Ask
  • How long is the drive?
    It takes about 1 hour.
  • Is there a train?
    Amtrak serves Durham, but there is no direct train from Winston-Salem.
  • Is it a safe route?
    Yes, but traffic can be stressful.
  • What is the best time to leave?
    Leave early in the morning to avoid traffic.
  • Are there tolls?
    There are minimal tolls on this route.
Quick Info
  • From Winston-Salem, North Carolina, United States
  • To Durham, North Carolina, United States
  • Modes
Best Time to Travel

Mid-day to avoid the heavy commuter traffic on I-40.

Things to Do in Durham
1
Duke University
A world-class university with a beautiful campus. It is a must-visit.
2
Sarah P. Duke Gardens
A stunning garden with diverse plant collections. It is a must-visit.
3
Durham Performing Arts Center
A premier performing arts venue. It is very popular.
4
Museum of Life and Science
An interactive science museum with exhibits on nature and technology. It is great for families.
Tags
Winston-Salem to Durham drive I-40 travel Durham travel guide Winston-Salem transport Durham commute North Carolina travel local commute