Driving
Winston-Salem to Durham
Updated: 28 May 2026
The distance from Winston-Salem to Durham is approximately 70 miles. The most practical way to travel is by driving east on I-40. The drive takes about 1 hour. This route is a major corridor for travel in the Piedmont region of North Carolina.
Total Distance: 115 km driving distance; 100 km straight-line air distance.
Fastest Way
Driving is the fastest way to reach Durham.
Cheapest Way
Driving is the most practical and cost-effective way to travel this distance.
Compare Winston-Salem to Durham Routes
Driving
Direct
Duration
1 hour
Avg Price
$10-$20 in fuel
Operator
Personal Vehicle
Route
Take I-40 East directly into Durham.
I-40 is very busy; check traffic before you leave.
Travel Tips
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DrivingI-40 is very busy; avoid driving during rush hour.
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ParkingParking in Durham can be expensive; use public transit.
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WeatherNorth Carolina weather is generally mild; pack accordingly.
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TrafficCheck traffic before you leave to avoid delays.
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TollsThere are minimal tolls on this route.
Safety Tips
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Personal SafetyStay in well-lit, populated areas in Durham.
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EmergencyKeep your phone charged and have a map of the city saved offline.
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Highway SafetyI-40 requires constant attention; stay alert.
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Vehicle SecurityNever leave valuables in your car.
People Also Ask
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How long is the drive?It takes about 1 hour.
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Is there a train?Amtrak serves Durham, but there is no direct train from Winston-Salem.
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Is it a safe route?Yes, but traffic can be stressful.
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What is the best time to leave?Leave early in the morning to avoid traffic.
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Are there tolls?There are minimal tolls on this route.
Quick Info
- From Winston-Salem, North Carolina, United States
- To Durham, North Carolina, United States
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Modes
Best Time to Travel
Mid-day to avoid the heavy commuter traffic on I-40.
Things to Do in Durham
1
Duke University
A world-class university with a beautiful campus. It is a must-visit.
2
Sarah P. Duke Gardens
A stunning garden with diverse plant collections. It is a must-visit.
3
Durham Performing Arts Center
A premier performing arts venue. It is very popular.
4
Museum of Life and Science
An interactive science museum with exhibits on nature and technology. It is great for families.
Tags
Winston-Salem to Durham drive
I-40 travel
Durham travel guide
Winston-Salem transport
Durham commute
North Carolina travel
local commute
