Is there a bus to Salisbury?

There is no direct public bus service from Millsboro to Salisbury.

How long is the drive?

The drive is approximately 35 minutes.

Is Salisbury a good place to visit?

Yes, it offers a mix of history, nature, and shopping.

No, there is no passenger rail service to Salisbury.

Millsboro

Salisbury

Driving

Millsboro to Salisbury

Updated: 28 May 2026

Salisbury, Maryland, is a major regional hub located 25 miles south of Millsboro. The most direct route is via US-113 South, which takes you across the state line. The drive is typically 35 minutes. This route is a primary artery for the Delmarva Peninsula, connecting rural Delaware to the commercial center of Salisbury.

Total Distance: 40 km driving distance; 38 km straight-line air distance.

Fastest Way

Driving via US-113 is the fastest, taking about 35 minutes.

Cheapest Way

Driving your own vehicle is the most cost-effective way to reach Salisbury.

Compare Millsboro to Salisbury Routes

Driving

Direct

Duration

35 mins

Avg Price

$8 in fuel

Operator

Personal Vehicle

Route

US-113 South directly into Salisbury.

US-113 is a straightforward highway with few turns.

Travel Tips

Traffic
Traffic is generally light, but watch for local school zones during morning and afternoon hours.
Parking
Downtown Salisbury offers free parking in several municipal lots.
Navigation
US-113 is well-marked, making it very easy to navigate without GPS.
Dining
Salisbury has a wide variety of restaurants, especially along the US-13 corridor.
Events
Check the city calendar for events at the Wicomico Youth & Civic Center.

Safety Tips

Speeding
Be aware of changing speed limits as you pass through small towns on US-113.
Road Conditions
The road is well-maintained, but be cautious of farm equipment during harvest seasons.
Emergency
Peninsula Regional Medical Center is located in the heart of Salisbury.
Visibility
Rural sections of US-113 are dark at night; use high beams where appropriate.