Perryville
Perryville
Houston
Houston
Driving

Perryville to Houston

Updated: 01 Jun 2026

The drive from Perryville to Houston is approximately 780 miles. You will head southwest through Arkansas and Louisiana before entering Texas. The journey takes about 12 hours via I-49 and I-45. This route takes you through the heart of the South and into the Lone Star State.

Total Distance: 1255 km driving distance; 1050 km straight-line air distance.
Fastest Way
Driving via I-49 and I-45 is the fastest, taking 12 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective method.
Compare Perryville to Houston Routes
Driving
Direct
Duration
12 hours
Avg Price
$130-$160 in fuel
Operator
Personal Vehicle
Route
I-55 to I-40 to I-49 to I-45 South.

Houston traffic is very heavy; plan your arrival accordingly.

Travel Tips
  • Traffic
    Avoid the Houston loop (I-610) during rush hour.
  • Dining
    Try authentic Tex-Mex or barbecue.
  • Navigation
    Use GPS to navigate the complex highway interchanges in Houston.
  • Parking
    Use public parking garages; street parking is difficult.
  • Timing
    Try to arrive in Houston mid-day to avoid the worst traffic.
Safety Tips
  • Driving
    Stay alert on the long stretches of highway.
  • Weather
    Be aware of potential flooding during heavy rain.
  • Vehicle
    Check your tire pressure before the long drive.
  • Emergency
    Keep a roadside emergency kit in your vehicle.
People Also Ask
  • Is there a train?
    No, there is no passenger rail service to Houston.
  • How long is the drive?
    It takes about 12 hours.
  • What is the best route?
    I-49 and I-45 are the most direct highways.
  • Are there tolls?
    Some express lanes in Houston have tolls; check your route.
  • Is it a safe drive?
    Yes, it is a standard interstate route.
Quick Info
  • From Perryville, Missouri, United States
  • To Houston, Texas, United States
  • Modes
Best Time to Travel

Spring or autumn for mild weather.

Things to Do in Houston
1
Space Center Houston
Visit the official visitor center of NASA's Johnson Space Center.
2
Museum District
Explore the many museums in this cultural hub.
3
Buffalo Bayou Park
Enjoy walking and biking trails along the bayou.
4
The Galleria
Shop at one of the largest malls in the country.
Tags
Perryville to Houston I-49 I-45 route driving to Houston Perryville travel fastest way to Houston Texas road trip Houston tourism Missouri to Texas