Yes, Greyhound offers service from nearby Cape Girardeau to Kansas City.

How long is the drive?

It takes approximately 5.5 hours.

What is the best route?

I-70 West is the most direct highway.

No, I-70 in Missouri is toll-free.

Yes, it is a standard interstate route with frequent services.

Perryville

Kansas City

Driving

Perryville to Kansas City

Updated: 01 Jun 2026

Traveling from Perryville to Kansas City involves crossing the state of Missouri from east to west. You will typically take I-55 North to St. Louis, then transition to I-70 West. The total distance is approximately 350 miles. Expect a drive time of roughly 5 hours and 30 minutes. This route takes you through the heart of the Show-Me State.

Total Distance: 563 km driving distance; 480 km straight-line air distance.

Fastest Way

Driving via I-70 is the fastest, taking about 5.5 hours.

Cheapest Way

Driving your own car is the most economical way to reach Kansas City.

Compare Perryville to Kansas City Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

$60-$80 in fuel

Operator

Personal Vehicle

Route

I-55 North to St. Louis, then I-70 West to Kansas City.

Expect heavy traffic through the St. Louis metro area.

Travel Tips

St. Louis Bypass
Use I-270 to bypass downtown St. Louis traffic during peak hours.
Rest Stops
Columbia, Missouri, is the perfect halfway point for a meal.
Speed Traps
Be cautious of speed limit changes in small towns along I-70.
Navigation
Download offline maps as signal can be spotty in rural areas.
Parking
Use the KC Streetcar for free travel within the downtown area.

Safety Tips

Fatigue
Take breaks every two hours to avoid driver fatigue on the long I-70 stretch.
Weather
Be aware of potential severe thunderstorms during spring months.
Road Conditions
Check the MoDOT website for construction updates before departing.
Emergency
Keep a roadside emergency kit in your trunk at all times.