Is there a train to Memphis?

No, there is no direct passenger rail service from Perryville to Memphis.

How long is the drive?

The drive takes approximately 3 hours depending on traffic.

What is the best highway?

Interstate 55 South is the primary and most direct route.

No, this route does not have any toll roads.

There are no commercial airports in Perryville; you must drive to St. Louis first.

Perryville

Memphis

Driving

Perryville to Memphis

Updated: 01 Jun 2026

The journey from Perryville to Memphis spans approximately 200 miles via Interstate 55 South. You will traverse the Mississippi River delta region, passing through the bootheel of Missouri. The drive typically takes 3 hours under normal traffic conditions. This route is primarily a straight shot south through Arkansas and Tennessee borders. It is the most efficient way to reach the home of the blues from Southeast Missouri.

Total Distance: 322 km driving distance; 280 km straight-line air distance.

Fastest Way

Driving via I-55 South is the fastest, taking exactly 3 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method for this distance.

Compare Perryville to Memphis Routes

Driving

Direct

Duration

3 hours

Avg Price

$35-$50 in fuel

Operator

Personal Vehicle

Route

I-55 South through Sikeston and Blytheville.

Check traffic near the I-55/I-40 interchange in West Memphis for delays.

Travel Tips

Fuel Up
Fill your tank in Sikeston, Missouri, to avoid higher prices near the state line.
Traffic Alerts
Use a real-time GPS app to monitor construction on the I-55 bridge.
Parking
Use the parking garages near Beale Street for secure vehicle storage.
Dining
Try authentic Memphis dry-rub ribs at Central BBQ.
Timing
Avoid departing during Friday afternoon rush hour to save time.

Safety Tips

Speed Limits
Strictly observe speed limits in small towns along the Missouri bootheel.
Weather
Watch for heavy rain or fog when crossing the Mississippi River bridges.
Vehicle Check
Ensure your tires are properly inflated for the long highway stretch.
Emergency
Keep a physical map in your glove box in case of cellular dead zones.