Perryville
Perryville
Louisville
Louisville
Driving

Perryville to Louisville

Updated: 01 Jun 2026

The journey from Perryville to Louisville covers approximately 320 miles. You will travel east through Illinois and Indiana before crossing into Kentucky. The drive takes about 5 hours via I-64. This route is a great way to see the heart of the Midwest and the Ohio River Valley.

Total Distance: 515 km driving distance; 440 km straight-line air distance.
Fastest Way
Driving via I-64 is the fastest, taking 5 hours.
Cheapest Way
Driving your own vehicle is the most affordable option.
Compare Perryville to Louisville Routes
Driving
Direct
Duration
5 hours
Avg Price
$55-$75 in fuel
Operator
Personal Vehicle
Route
I-64 East through Mount Vernon and Evansville.

Watch for speed limit changes in Indiana.

Travel Tips
  • Traffic
    Expect some congestion when crossing the Ohio River into Louisville.
  • Dining
    Try a Hot Brown sandwich at a local restaurant.
  • Navigation
    Use GPS to navigate the complex highway interchanges in Louisville.
  • Parking
    Downtown parking is plentiful but can be expensive during events.
  • Timing
    Avoid traveling during the Kentucky Derby weekend unless you have reservations.
Safety Tips
  • Driving
    Stay alert on the long stretches of I-64 in Indiana.
  • Weather
    Be aware of fog near the Ohio River in the early morning.
  • Vehicle
    Check your oil and tire pressure before the long drive.
  • Emergency
    Keep a spare tire and jack in your vehicle.
People Also Ask
  • Is there a train?
    No, there is no passenger rail service to Louisville.
  • How long is the drive?
    It takes about 5 hours.
  • What is the best route?
    I-64 East is the most direct highway.
  • Are there tolls?
    Some bridges in Louisville have tolls; check your route.
  • Is it a safe drive?
    Yes, it is a standard interstate route.
Quick Info
  • From Perryville, Missouri, United States
  • To Louisville, Kentucky, United States
  • Modes
Best Time to Travel

May for the Kentucky Derby or autumn for beautiful foliage.

Things to Do in Louisville
1
Churchill Downs
Visit the home of the Kentucky Derby and the racing museum.
2
Louisville Slugger Museum
See how the famous baseball bats are made.
3
Muhammad Ali Center
Explore the life and legacy of the legendary boxer.
4
Big Four Bridge
Walk across this pedestrian bridge for great views of the Ohio River.
Tags
Perryville to Louisville I-64 route driving to Louisville Perryville travel fastest way to Louisville Kentucky road trip Louisville tourism Missouri to Kentucky