Chicago, Illinois, is located 800 miles west of Millsboro. The most direct driving route is via I-76 and I-80, taking approximately 13-14 hours. Alternatively, you can drive to Philadelphia International Airport (PHL) for a direct flight to Chicago (ORD), which takes about 2.5 hours in the air. This is a major journey across the United States.
Total Distance: 1,280 km driving distance; 1,100 km straight-line air distance.
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Direct from PHL
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Direct
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| Duration | 5 hours (including airport time) | 13 hours 30 mins |
| Avg Price | $150-$350 | $200 in fuel and tolls |
| Operator | United/American Airlines | Personal Vehicle |
| Route | Drive to PHL, fly to ORD. | US-113 N to I-76 W, then I-80 W to Chicago. |
| Tip | Book flights in advance for the best rates. | Use E-ZPass for tolls on the Pennsylvania Turnpike. |
Spring and Fall to avoid the harsh winter and hot summer of the Midwest.