No, there is no passenger rail service to San Antonio.

What is the best route?

I-35 South is the most direct highway.

Some express lanes in San Antonio have tolls; check your route.

Yes, it is a standard interstate route.

Perryville

San Antonio

Driving

Perryville to San Antonio

Updated: 01 Jun 2026

The drive from Perryville to San Antonio is approximately 900 miles. You will head southwest through Arkansas and Texas. The journey takes about 14 hours via I-35. This route is a popular path for those traveling from the Midwest to South Texas.

Total Distance: 1450 km driving distance; 1200 km straight-line air distance.

Fastest Way

Driving via I-35 is the fastest, taking 14 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method.

Compare Perryville to San Antonio Routes

Driving

Direct

Duration

14 hours

Avg Price

$150-$180 in fuel

Operator

Personal Vehicle

Route

I-55 to I-40 to I-30 to I-35 South.

San Antonio traffic is very heavy; plan your arrival accordingly.

Travel Tips

Traffic
Avoid the San Antonio highway loops during rush hour.
Dining
Try authentic Tex-Mex cuisine.
Navigation
Use GPS to navigate the complex highway interchanges in San Antonio.
Parking
Use public parking garages; street parking is difficult.
Timing
Try to arrive in San Antonio mid-day to avoid the worst traffic.

Safety Tips

Driving
Stay alert on the long stretches of highway.
Weather
Be aware of potential severe weather in Texas.
Vehicle
Check your tire pressure before the long drive.
Emergency
Keep a roadside emergency kit in your vehicle.