Perryville
Perryville
San Diego
San Diego
Driving

Perryville to San Diego

Updated: 01 Jun 2026

The drive from Perryville to San Diego is approximately 1,950 miles. You will head west through Oklahoma, Texas, New Mexico, and Arizona. The journey takes about 29 hours via I-40. This is a cross-country route connecting the Midwest to the West Coast.

Total Distance: 3140 km driving distance; 2700 km straight-line air distance.
Fastest Way
Driving via I-40 is the fastest, taking 29 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective method.
Compare Perryville to San Diego Routes
Driving
Direct
Duration
29 hours
Avg Price
$310-$350 in fuel
Operator
Personal Vehicle
Route
I-55 to I-40 to I-15 South.

San Diego traffic is very heavy; plan your arrival accordingly.

Travel Tips
  • Traffic
    Avoid the San Diego highway loops during rush hour.
  • Dining
    Try the many international restaurants.
  • Navigation
    Use GPS to navigate the complex highway interchanges in San Diego.
  • Parking
    Use public parking garages; street parking is difficult.
  • Timing
    Try to arrive in San Diego mid-day to avoid the worst traffic.
Safety Tips
  • Driving
    Stay alert on the long stretches of highway.
  • Weather
    Be aware of potential severe weather in the desert.
  • Vehicle
    Check your tire pressure before the long drive.
  • Emergency
    Keep a roadside emergency kit in your vehicle.
People Also Ask
  • Is there a train?
    No, there is no passenger rail service to San Diego.
  • How long is the drive?
    It takes about 29 hours.
  • What is the best route?
    I-40 is the most direct highway.
  • Are there tolls?
    Some express lanes in San Diego have tolls; check your route.
  • Is it a safe drive?
    Yes, it is a standard interstate route.
Quick Info
  • From Perryville, Missouri, United States
  • To San Diego, California, United States
  • Modes
Best Time to Travel

Spring or autumn for mild weather.

Things to Do in San Diego
1
San Diego Zoo
Visit the world-famous zoo.
2
Balboa Park
Explore the park and museums.
3
La Jolla Cove
Enjoy the beach and sea lions.
4
USS Midway Museum
Visit the historic aircraft carrier.
Tags
Perryville to San Diego I-40 route driving to San Diego Perryville travel fastest way to San Diego West Coast road trip San Diego tourism Missouri to California